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The Pearl®
Impulse Imager

Cat. No. LIC-9400-00



With the Pearl® Impulse Imager, you can:

  • Visualize imaging agents dynamically with real-time imaging
  • Use native cells and cell lines for in vivo imaging, without reporter genes
  • Achieve exceptional sensitivity and deep target imaging with laser excitation and near-infrared fluorescent detection
  • Detect two near-infrared probes simultaneously
  • Acquire optimized images quickly with one-button operation
  • Use validated targeting agents to get started immediately without developing your own agents

 

Overview & Advantages
Excellent Sensitivity
Laser-based excitation and near-infrared detection result in exceptional sensitivity, with deeper tissue penetration
and earlier target detection.

Fast Imaging
Rapid, one-button acquisition of 700nm, 800nm, and white light images enables quick screening of animals
and simultaneous detection of different targets.

Native Cell Compatibility
Using IRDye® targeting agent solutions for fast research startup – without reporter gene transfection or
cell line development.

Enviromental Control
With HEPA-filtered imaging beds for immunocompromised animals, docking stations and anesthesia systems.

 

Applications for the Pearl Impulse Imager System

  • Small Animal Imaging
  • Receptor Targeting
  • Transporter Targeting
  • Structural Imaging
  • Biodistribution
  • Vascular/Lymphatic Imaging

 

Workstation
Build a Complete Solution

Combining the Odyssey® Infrared Imaging System with the Pearl® Impulse Imager creates a versatile workstation for in vivo and in vitro imaging. Probes developed using an IRDye® near-infrared dye can be used for evaluation of binding capacity in vitro, in vivo imaging and tissue imaging.


Odyssey® Imaging System Capabilities

  • Cell-based assays (binding capacity, specificity, competition, etc.) for optical agent development.
  • Histology and whole organ imaging for studying clearance and specificity.
  • Simultaneous two-colour detection for two targets or one target with sample normalization.

 

Specifications:

  Pearl® Imager Pearl® Impulse
Detector Type CCD. Thermoelectrically cooled. CCD. Thermoelectrically cooled.
Scan Time Less than 30 seconds to complete white light, 700nm channel and 800nm channel image acquisition. Less than 30 seconds to complete white light, 700nm channel and 800nm channel image acquisition.
Maximum Wavelength for Excitation/Emission Bands
700 nm Channel Excitation 685nm, Emission 720nm Excitation 685nm, Emission 720nm
800 nm Channel Excitation 785nm, Emission 820nm Excitation 785nm, Emission 820nm
White Channel Excitation white, Emission, NA Excitation white, Emission, NA
Dyes IRDye® 680, IRDye 700DX, IRDye 800RS, IRDye 800CW, Alexa Fluor® 680, Alexa Fluor 750, Cy5.5, Cy7 IRDye® 680, IRDye 700DX, IRDye 800RS, IRDye 800CW, Alexa Fluor 680, Alexa Fluor 750, Cy5.5, Cy7
Resolution 85 or 170 micron 85, 170 or 255 micron
Image Display Options Pseudocolour, grayscale, single colour (red, green or blue), or two colours with overlapping fluorescence displayed in a third colour. Pseudocolour, grayscale, single colour (red, green or blue), or two colours with overlapping fluorescence displayed in a third colour.
Capacity One animal, with linked look-up tables for image normalization. One animal, with linked look-up tables for image normalization.
Imaging Bed 16.8cm W x 12cm D (6.6” W x 4.75” D). Vertical clearance to top of drawer is 3.8cm (1.5”). 16.8cm W x 12cm D (6.6” W x 4.75” D). Vertical clearance to top of drawer is 3.8cm (1.5”).
Field of View 11.2cm W x 8.4cm D (4.4” W x 3.3” D) at surface of imaging bed. 11.2cm W x 8.4cm D (4.4” W x 3.3” D) at surface of imaging bed.
Imaging Bed Temperature Range 32-42°C. 32-42°C.
Gas Anesthesia Inlet and outlet ports flow anesthesia gas through a nose cone in the imaging drawer. A rotameter is included for flow rate control. Inlet and outlet ports flow anesthesia gas through a nose cone in the imaging drawer. A rotameter is included for flow rate control.
Size 41 W x 41 D x 66cm H (16” W x 16” D x 26” H). Depth with imaging drawer open is 63.5cm (25”). 41 W x 41 D x 66cm H (16” W x 16” D x 26” H). Depth with imaging drawer open is 63.5cm (25”).
Weight 2 kg (50 lb) 23kg (50 lb)
Acquisition Speed ~30s 500ms - 40s
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