A Higher Standard for Confident Compliance Capability

Shimadzu's GCMSsolution software sets a new standard for laboratory productivity in the 21st century by offering new and innovative solutions to the challenges of high-sample throughput, instrument control, diverse data handling, and integration with regulatory compliance.

Version 2.2 for the QP-2010 has improved data peak processing with multiple background subtraction and improved manual integration. It offers spectrum correction for coelutions or contaminants, including subtraction of spectra and library searching of the resulting spectrum for better qualitative processing, as well as an enhanced library search capability.

One-Window Technology
Many innovative ideas are included in the GCMSsolution software. Our software engineers have worked with our customers to create the most complete and friendly instrument control and processing software for our GC/MS systems. With "one-window" design, the user can simplify operation and put total control within the reach of the mouse.

'One-window' means that all data reduction information is now visible on one screen. Changing parameters for the viewed compound in the quantitation table simultaneously changes the display for the quantitative results, peak integration, spectrum, ion ratio, and peak locator on the TIC.

'One-window' also means that compound calibration, private library editing, chromatogram comparison, and reporting software are accessed from the same place. Use the right mouse button to perform manual integration, search for matches in any commercial library, or identify chromatographic peaks with the base peak m/z. It's Simple and Easy!

Improved Method Development
Acquisition parameters for the GC oven, AFC flow and pressure profiles are displayed behind the TIC trace. Constant Linear Velocity optimizes separation with one-button operation. Tune the GC/MS by setting the software ion ratios, and GCMSsolution delivers every time. On the "acquire" display, a reference chromatogram behind the acquisition trace speeds method development. Changes to all method parameters are made graphically. The ability to time-program the GC and MS is standard. High-speed GC/MS, high-pressure injection mode, Programmed Temperature Vaporization and Large-Volume Injection (PTV/LVI) are unique capabilities offered by GCMSsolution in conjunction with our AOC-20 autosampler.

Analytical Flexibility
Scan up to 50 times per second or select 64 ions in 64 ion sets in SIM mode. It is now possible to run SIM and Scan modes in a single analytical run. SIM mode can be used when a target analyte is expected to elute, and full scan mode when no target analytes are expected. With Lab Solutions you can switch from scan to SIM 64 times within an analysis. Calibrate using 64 concentrations and up to 10 level repeats with 64 internal standards for maximum flexibility. Use any curve fit method that your work requires and set the fit type individually for each compound. Curve fits for internal and external standard with mean response, linear regression, and multi-point modes are included. To simplify methods maintenance set the detector voltage for acquisition relative to the tune profile. This means you never have to manually update a method file again.

Simply Powerful Quantitation

Post-run processing places all needed information for quantitation visually available and graphically accessible. The Data Explorer keeps the working project visible and a simple "click and drag" loads the data file. Search for file visually on the Preview window below the file or icon list.

The chromatogram window presents TIC, extracted ion profiles, SIM profile, Multiple Ion Chromatographs with integration, compound name labeling, and base peak m/z labels to easily identify the peaks.

The spectrum shown is generated from the integrated peaks or from manual spectrum generation and background subtraction. Right- mouse clicking provides library search results from any commercial library or up to 5 total libraries in any search.

The compound table holds the identification information for ion ratios or full spectrum scan data. By using scan spectrum, GCMSsolution provides more accurate compound identification and the "Compound Finder" can locate a compound anywhere in the chromatogram, ensuring easy method transfer between instruments and when changing columns.

Version 2.2 features a batch quantitation browser with reprocess, requantitation and reporting of multiple compounds and files from the browser window. Enhanced multiple spectrum chromatograph data comparison allows users to overlay chromatographs for improved analysis of varying data matrix samples.

Second Detector Option
QP-2010 adds a two-dimensional detector (FID or TCD) that makes GCMSsolution our most complete and flexible software package.

Wizards Work for You
Wizards lead you through creating methods, target compound tables, and batch acquire tables to simplify the process of using the system. Integration parameters, curve type, fit, and more are set using the wizard. Analyze all compounds using the same calibration type or each compound can have individual performance monitoring criteria.

Compound Table Wizard
The Compound Table Wizard leads you through the sequence of operations to build a compound table with minimum effort. New or experienced users can easily create the table for quantitative analysis by only typing the name for each identified peak.

Select calibration method fit parameters for the list, then select the peaks to be included. Group peaks as needed to quantitate multiple peak measurements easily and accurately.

Batch Table Wizard
Creating new batch tables in GCMSsolution is simple. Each line of a batch can have visual basic programmability for pre-run, post-run or decision-based operations. Post-run or run-mode processing allows GCMSsolution to control and integrate many other lab systems functions into one automated process. This minimizes the required time to perform your research.

Select table entries in two ways: (1) by viewing the spectra and selecting the proper compounds for the quantitation table, or (2) by first processing the results into the spectrum process table, then selecting from the list of library-searched names. "Next functionality" guides you through the process and allows you to change or verify setup with minimum effort.

Method Wizard
Set up parameters for analyzing samples using the GCMS-QP2010 automatically with the Method Wizard. Create simple or complex assays quickly and accurately. From the most experienced to new users, the wizard speeds your method development.

Features of GCMSsolution Version 2.2

Quantitation Batch Viewer and Summary Printout
This advanced program allows multiple files to be simultaneously viewed and quantitatively reprocessed. Included are the capabilities to perform batch summary calculations for the entire batch as a run set, and to check calibration linearity while verifying the sample file data within the batch. Report the calibration and quantitation outputs for the batch without exiting the Batch Summary Window.

Multiple Point Background Subtraction
By taking background points before and after a qualitative peak, unknown samples are more easily identified.

Manual Spectrum Correction from the Mass Table with Library Search
When manual spectral correction is needed for column bleed or other known contaminants, they are removed from the mass table allowing better library search results.

Subtraction of Library Spectrum from a Target with Research of Resulting Spectrum Subtracting one library spectrum from the target removes the spectrum from the co-elution, providing a better match for the second of the time-coincident peaks.